Synthesis of API’s and API’s based Derivative

Synthesis of API’s and API’s based Derivative Title of Proposed Project: Efficient synthesis of API’s and API’s based Derivative for their Structure Activity Relationship and Pharmacokinetics Profile Project Details Project Summary This project concern with the establishment of organic synthesis facilities in Department of Chemistry, UNIVERSITY OF KARACHI. The established facilities will be used for the training of BS/M.Sc./MS/M.Phil. And Ph.D. scholars in the field of Organic Synthesis. In this project we will focus on the establishment of synthetic organic laboratory, the synthesis of the two API’s (Secnidazole Atenolol). We are requiring the following basic facilities which we want to establish by this research project. Facilities required for: Organic Synthesis Fuming HOODs for save, non-hazardous and smooth working at the moment. Inert atmosphere working conditions since many organic reactions requires inert condition. Safety equipment’s i.e. firefighting equipment’s, washing shower in case of chemical accident and first aid facilities. (UPS) as regular power breakdown results in the unsuccessful reactions and causing faults in the electronic instruments. UV lamp as processing of many reaction monitor under UV light. Rotary evaporator Partial availability of glass wares. MAS-II Microwave workstation for repaid synthesis of APIs. Proposed Goals / Objectives Hypothesis / Basis of research The purpose of this project is to setup a laboratory which can design (Organic Synthesis) and synthesize (Organic Synthesis) the APIs for the local Pharmaceutical industry along with the establishment of the required facilities. The following APIs will be synthesized. ATENOLOL Efficient Synthesis of Atenolol. Synthesis of Atenolol based derivatives for Structure-Activity Relationship Studies (SARS) and their pharmacokinetics profile SECNIDAZOLE Efficient Synthesis of Secnidazole Synthesis of Secnidazole based derivatives for Structure-Activity Relationship Studies (SARS) and their pharmacokinetics profile Goals / Objectives Boost up economy of Pakistan Synthetic solution for local industry. Provide sufficient amount of these drugs to common people. INTRODUCTION API stands for active pharmaceutical ingredients and its covers a lot of pharmaceutically active compounds which has great importance in industry as well as to common people as the insufficiency of these drugs causes hundreds of death. Due to the importance of API we decided to work with the synthesis of API as it will create the impact of API research on national level. The synthesis of API could decrease the import bill of such active ingredient in Pakistan and also opens the opportunity of job. This project could provide a platform to save the foreign currency reserves and supply sufficient amount of drugs to common people at low cost. Ours Efforts will be enabling to purpose the more efficient synthesis of complex molecules. In this project we have design the synthesis of the following APIs ATENOLOL Efficient Synthesis of Atenolol. Synthesis of Atenolol based derivatives for Structure-Activity Relationship Studies (SARS) and their pharmacokinetics profile SECNIDAZOLE Efficient Synthesis of Secnidazole Synthesis of Secnidazole based derivatives for Structure-Activity Relationship Studies (SARS) and their pharmacokinetics profile 4a) Background of the Research Problems to be addressed Secnidazole (Part: A) Efficient Synthesis of Secnidazole Secnidazole is a molecule which belongs to the class of 5-nitroimidazole and it is considerably more effective than other imidazole drugs. It is the important API required for the local industry. However it has been used for the treatment of amoebiasis, giardiasis, urogenital trichomoniasis and nonspecific bacterial vaginosis and also a gel formulation of secnidazole was developed for the treatment of periodontitis. . All nitroimidazoles are synthetic drugs such as metronidazole. Tinidazole, dimetridazole, secnidazole and ornidazole. Among all these we selected secnidazole because of its High efficacy. Secinidazole is the mainly use for antiprotozoal activity and its single dose possess three days anti protozoal activity. Figure 1: Chemical Structure IUPAC Name:1-(2-methyl-5-nitro-1H-imidazol-1-yl) propan-2-ol Figure 2: Proposed Two-Step Synthesis route for Secnidazole After observing the reaction condition and UV-Vis absorption, FTIR, ESI-MS and NMR results. The purposed scheme will be optimized. Synthesis of Secnidazole based derivatives for Structure-Activity Relationship Studies (SARS) and their pharmacokinetics profile Pharmacological and pharmacokinetic properties of existing drugs can be enhanced by chemical modifications. A prodrug (drug transporter) formation is a great approach to improve and modify the physio chemical properties of the drug, boost up its concentration at the site of action, extend its period of action and decrease its toxicity. Regarding 5–7% of drugs approved worldwide are categorized as prodrug. Prodrugs are the reversible, inactive or less active derivatives of a drug. Prodrugs are hydrolyzed either by enzymatically or non-enzymatically to discharge parent drug while the co-drugs (mutual prodrug) are the special type of prodrug in which two or more pharmacologically active pro moieties exist via chemical bond to release two or more parent drugs upon the cleavage of bond by enzymatically or chemically. The variety of chemical linkages used in the formation of Prodrugs. Although the ester formation is common followed by imides, amide and carbamate derivative. Thatâ₠¬â„¢s why in this project our aim is to synthesize the prodrug for its better mode of action and their structure activity relationship and their pharmacokinetics profile. ATENOLOL (Part: B) Efficient Synthesis of Atenolol Atenolol (ATN) belongs to the class of drug called beta-blockers. Beta-blockers (beta adrenoreceptor antagonists) are basically competitive inhibitor that’s inhibits the action of stimulating hormones on beta adrenergic receptors in the nervous system. Atenolol works by competing for receptors sites on cardiac muscle. This slow down the strength of heart‘s contractions and reduce its oxygen requirements and the volume of blood it has to pump. Atenolol is one of the extensive used active pharmaceutical ingredients (API) for the treatment of Hypertension, myocardial infarction (Heart attack), Arrhythmias (rhythms disorder), Angina (chest pain) and disorder arising from decreased circulation of blood. Figure 1: Chemical Structure IUPAC Name:2-[4-[2-hydroxy-3-(propan-2-ylamino) propoxy] phenyl] acetamide Figure 2: Proposed Two-Step Synthesis route for Atenolol The stereochemistry is important for any molecules. In atenolol (S) isomer is important for its activity the opposite (R) enantiomer may be responsible for the side effects. There have been considerable efforts done in the preparation of enantiomerically pure(S) confirmation Synthesis of Atenolol based derivatives for Structure-Activity Relationship Studies (SARS) and their pharmacokinetics profile On the basis of the importance of prodrug (mention above part) our aim is to synthesize the prodrug for its better mode of action and their structure activity relationship and their pharmacokinetics profile. 4B.RESEARCH PLAN/ METHODOLOGY: SCHEDULE/PHASING Establishment of Organic Synthesis Facilities: In the starting 1st months of this project all the basic and reaction requirement apparatus and glassware will be installing. Efficient Synthesis of SECNIDAZOLE: After initialization, the starting 3 months will be utilized on the proposed and modified efficient synthesis of Secnidazole to get the maximum yield of required API at minimum cost. Synthesis of SECNIDAZOLE based derivatives for SARS: In the 5th and 6th month modification on the molecule of Secnidazole will be applied and study their pharmacokinetics profile Synthesis of ATENOLOL: In the period of 7th to 9th month of the project efficient synthesis of atenolol will be done Synthesis of ATENOLOL based derivatives for SARS: In the period of 10th to 11th month of the project timeline, derivatization of atenolol will be carried out and studied their pharmacokinetics profile Summarize results and expand to new project: At the end month of this project timeline a final project report will be submitted along with findings. Also discuss the achievements and problems faced during this project. 4c) References Secnidazole (Part: A) Larina, Lyudmila, and Valentin Lopyrev.Nitroazoles: synthesis, structure and applications. New York: Springer, 2009. Crozet, Maxime D., Cà ©line Botta, Monique Gasquet, Christophe Curti, Vincent Rà ©musat, Sà ©bastien Hutter, Olivier Chapelle, Nadine Azas, Michel De Mà ©o, and Patrice Vanelle. Lowering of 5-nitroimidazoles mutagenicity: towards optimal antiparasitic pharmacophore.European journal of medicinal chemistry44, no. 2 (2009): 653-659 Wang, She-Feng, Yong Yin, Fang Qiao, Xun Wu, Shao Sha, Li Zhang, and Hai-Liang Zhu. Synthesis, molecular docking and biological evaluation of metronidazole derivatives containing piperazine skeleton as potential antibacterial agents.Bioorganic medicinal chemistry22, no. 8 (2014): 2409-2415. Samanta, Himadri Sekhar, and Samit Kumar Ray. Controlled release of tinidazole and theophylline from chitosan based composite hydrogels.Carbohydrate polymers106 (2014): 109-120. Elias, P. cureforneedy.com 2009, 1-11. Shahid, Hafiz Abdullah, Ejaz Hussain, Sajid Jahangir, and Sammer Yousuf. 1-(2-Methyl-5-nitro-1H-imidazol-1-yl) propan-2-yl acetate.Acta Crystallographica Section E: Structure Reports Online70, no. 3 (2014): o294-o294. Atenolol (Part: B) Chaudhari, Vilas, Syed Hussain, and Milind Ubale. International Journal of Chemical Studies. Kitaori, Kazuhiro, Yoshikazu TAKEHIRA, Yoshiro FURUKAWA, Hiroshi YOSHIMOTO, and Junzo OTERA. A practical synthesis of optically active atenolol from chiral epichlorohydrin.Chemical and pharmaceutical bulletin45, no. 2 (1997): 412-414. Darnle, Subhash V., Prashant N. Patil, and Manikrao M. Salunkhe. Chemoenzymatic synthesis of (R)-and (S)-atenolol and propranolol employing lipase catalyzed enantioselective esterification and hydrolysis.Synthetic communications29, no. 22 (1999): 3855-3862 IMPACT OF PROPOSED RESEARCH The impact of this project will boost up the economy of Pakistan and will decrease the import bill of Pakistan and also increases the exportation. The project also aims to train the man power and create the skillful hand that can provide the better solution to our local industry. This project also creates the networking between the local industry and researcher. This project also contributes in the providing of the medicine to common people at minimum cost. Estimated Budget For The Proposed Research Period: DESCRIPTION PER YEAR Amount (in million Rs) A. Salaries and Honorarium PI: One Month/Year of Basic Pay @ 104000 0.104 (208000) Student Ships @ 20,000.00 per month (two) 480000 0.48 (480000) Secretariat Staff Part-time Lab Attendant @ 1500 PM 18000 0.018 (18000) Subtotal: (A) 602000 0.602 (602000) B. Permanent Equipment General purpose fume hood @ Pkr 150,000/= (two) 300000 0.600 (600000) The rotary evaporator  ® r 3 focuses and accessories @ Pkr 1500000 1500000 1.500 (1500000) Jacketed reaction apparatus @ Pkr 169650/= (one) 169650 0.1695 (169650) Glassware, hotplates, stirrer, etc. 250000 0.250 (250000) Laptop (dell core 2i) 50000 0.050 (50000) General lab update i.e. Ups and power supply solutions 250000 0.250 (250000) Mas II: microwave synthesis system @ $8000/= (one) 800000 0.800 (800000) Subtotal: (B) 3319650 3.319650 (3319650) C. Expendable Supplies Chemicals and solvents 300000 0.300 (300000) General lab expenditures 100000 0.100 (100000) Spectroscopy techniques 250000 0.250 (250000) Subtotal: (C) 650000 0.65 (650000) D. Others (Literature, documentation, information, online literature search, contingencies, postage, Local Travel Miscellaneous etc). Journal Publication Fee / Online Material (up to Rs.50,000) 50000 0.050 (50000) Stationary/Contingency (10,000/- per year) 10000 0.010 (10000) Participation in local conferences, workshops and winter summer schools by PI and students 10000 0.010 (10000) Audit Fee (Max. Rs 10,000) 10000 0.010 (10000) Accountant Fee (Max. Rs. 10,000) 10000 0.010 (10000) Subtotal: (D) 90000 0.090 (90000) Grand Total (A + B + C + D): 4661650 4.661650 (4661650) JUSTIFICATION Salaries Allowances Two Studentships @ 20,000.00 per month (PM): It is very necessary that at least two full time studentships available to students so that students can perform their work with piece of mind so that they have no need to sort part time jobs to meet their day to day expense Part-time Lab Attendant @ 1500 PM: During period of project operations different kind of tasks are assigned to Lab Attendant in addition to their normal job responsibilities. Therefore it is justified to compensate their work with an honorarium. Permanent Equipment: The Rotary Evaporator and accessories (one): Many organic reactions are in liquid phase and require much more time to evaporate on room temperature that’s why to save time and fast reaction process need rotary evaporator. General Purpose Fume Hood: As many organic reaction, chemicals and solvents are hazardous to human health. For safety and precautionary step need two fuming hoods Jacketed Reaction Apparatus: It is the temperature control apparatus. As many reaction are temperature dependent and monitor through varying temperature. to make reaction efficient we need jacketed reaction apparatus Glassware, Hotplates, Stirrer, refwork etc: These are the basics requirement for organic synthesis as well as we have shortage of these basics needs that’s why we need these General lab updates i.e. UPS and Power Supply solutions: Regular breakdown of power supply has resulted in the failure of organic reactions as well as damage of electronic appliances. Therefore a need to establish backup of power supply. Expendable supplies Chemicals and solvents: These play key role in all reaction either organic or inorganic and no one can performed reaction without this so these funding are fully justified General Lab Expenditures: these are the basic need for researcher to meet day to day expenses Participation in local conferences, workshops and winter/summer schools by PI and students: These funding are required to communicate our work on national and international level. Also learn gain information from their experience

Kate Chopin and the Awakening

What features make The Awakening a â€Å"local color† story? The amount of detail that is spent on the area and is significant. Every time a character that is colored is introduced, limited time is spent describing the character. Local color is what defines an area, town or people. â€Å"The Awakening† touches deeply on all of the local color of the area it is describing. What customs and beliefs of Edna Pontellier's society are significant in relation to her psychological development? To be a good person in Edna’s society meant being a mother figure who completely surrenders her sense of self in favor of her husband and children. Edna is trying to become a human being the best way she knows how. Edna refuses to take the mother road. Instead, she seeks her humanity What attitudes and tendencies in the Creole characters does Edna have trouble adjusting to? Creole society is very open when it comes to sexuality, and Edna has trouble with that. She was not brought up in the Creole society, so she has trouble accepting it. Examples can be seen when they pass around the novel that has explicit sexual content while on vaction. It can also be seen in Robert's behavior. He is very openly flirtatious with Edna, and he has the repuation of being a flirt in the past with other women. Why did Edna marry Leonce? Is he the model husband? She married him because she didn't want her father to choose her husband. She wanted the freedom of being able to choose herself. â€Å"Was he the best choice? † Probably not for Edna but it was who she chose. What incidents in the novel reveal that he may not be a good husband for Edna? As a traditional Creole gentleman of the times, Leonce believes it is his duty to provide financially for the family and it is Edna's duty to be devoted to him, their two children, and their home. When Edna suggests she is not interested in these domestic duties, Leonce is incapable of comprehending what she means. In his mind, this line of thinking is utterly ridiculous. Against that backdrop, Leonce's inability to communicate effectively with his wife expands the problem. When Edna shares her feelings with Leonce, he dismisses them. When her behavior contradicts his expectations, he dismisses them. By dismissing Edna and her concerns and never communicating with her about them, Leonce severs any ties that exist between the two. How do Mlle. Reisz and Mme. Ratignolle function in relation to Edna and the novel's view of women as mothers and artists? Mme. Ratignolle shows the society's view of women as mothers. Her advice to Edna is to â€Å"remember the children. † Ratignolle is loving and nurturing, but devoid of independence or personality. Mlle. Reisz, though, is living her life as she desires, not caring what society thinks of her. She is able to be extravagant and lavish, fully embracing her artistic capabilities because she does not have other obligations. She denies society's structure, and encourages Edna to do the same. This free lifestyle is what Edna comes to desire and seek for herself. What kind of mother is Edna? What kind of artist is she? Painting evokes the passion that Edna lacks in her life. There are suggestions that Edna's art is somehow flawed. Madame Reisz cautions Edna about what it takes to be an artist, the â€Å"courageous soul† and the â€Å"stronged wings. † Edna also loves her children, however she would not give herself to her children but rather sacriface herself for them. She realizes that she has lives in a society filled with limitations, therefore sees her only way out by freeing herself permanently from society. How are the background characters such as the young lovers and the lady in black at the shore, significant in Edna's story? These minor characters all serve to contrast with Edna and her struggles with her own identity and place in society. The young lovers are a stark contrast to the marriage of Edna and Leonce, at least as Edna perceives her marriage. The young lovers are described as walking shoulder to shoulder, suggesting they are equals and connected. Edna does not feel this with Leonce. The lady in black is likely an old widow who is now living out the end of her life in the expected way. She wears the color of mourning and serves as a visible picture of what the last phase of what life is like in this society. In detail, explain how the flashbacks to Edna's past function. How does her father compare to the other men in her life? In the first one, Edna is talking to Robert and recalls a â€Å"summer day in Kentucky, of a meadow that seemed as big as the ocean. † This memory reveals to us that Edna's interest in running away and being engulfed by something larger than itself has its manifestations in her childhood and is not something that she is just starting to consider as an unhappy wife and mother in Creole New Orleans. As the chapter progresses we learn that Edna had some â€Å"loves† in her past, but that they were more of her imagination than any possibility of reality. † With all of this flashback information, it comes as no surprise then that when Leonce woos her, even though she doesn't love him. Leonce is everything her father isn't, and that is part of his appeal. Edna even openly admits that the fact that Leonce is Catholic and that that would irritate her father is one of the reasons she agreed to marry him. This flashback gives us a very complete picture of Edna's history in regards to men and establishes the foundations of her marriage to Leonce. This has a great effect on the reading of the novel. It makes Edna's character more complex and more interesting How does the view of romantic love develop in the course of the novel? What is the doctor's view of marriage and childbearing? The genuine affection that develops between Edna Pontellier and Robert Lebrun is a form of romantic love. They shared their thoughts on a range of subjects that might appear uninteresting to others. As their friendship grew, they become more comfortable with one another. Robert rests his head on Mrs. Pontellier because it is comfortable. His goal is not to be forward or flirtatious. Roberts’s romantic feelings for Edna increase as this intimacy grows. Robert leaves for Mexico very soon afterwards. He hopes to escape his feelings because he realizes that he has fallen in love with Edna. His love developed naturally over time. His feelings morphed from a close friendship into emotional intimacy/understanding and then into love. Can you think of an emotional attachment and/or a romantic obsession you have studied in a previous work? How does that incident or character compare with Edna's emotional and romantic relationships? In a book i recently read, the main character's wife has a small dilema. She loves the man she is married to but rejects him at the same time. The reason she rejects him is because she was chosen as his wife and she did not get to choose him. Its a bit more complicated than this but this is a basic summary. This compares to Edna because she doesn't want a husband to choose her. She wants to choose the husband. She picks a man based on how he woos her nicely. This causes the ultimate problem that she ends up not loving her husband. The similarity is in the differences. Both took a different path to get to the same area. The end result was the same though. The women in the book I read, ran away. Edna committed suicide in order to run away. What are the main images and symbols in the novel? One of the main themes is the Sea. At the very end of the novel, Edna drowns herself. The irony of the scene is that Edna has learned how to swim, so here she is certainly exhibiting an act of agency by swimming far out into the water that used to scare her. Now, she is not scared and as she swims she recalls all the troubles and misunderstandings of her life. Her drowning symbolically represents her freeing herself from what she felt was a life of restriction. Here in the water, she experiences that which her life did not allow. The novel starts with the symbol of a caged bird, and references birds in several other chapters as well. The caged bird is a clear symbol for Edna as she feels caged in her roles of wife and mother and in the expectations that the Creole society has imposed on her. Later in the novel Reisz questions whether Edna has strong enough wings to fly above the social conventions of the time to be truly free of the rules and norms of the day. In the end, Edna sees a bird with a broken wing, just as she is not strong enough (or willing enough) to struggle on this society. Why does Edna get involved with Alcee Arobin? Alcee Arobin follows Edna around and spends a great deal of time with her while Mr. Pontellier is not home. At first it is just friendship, Edna takes no real interest in Alcee because her love lies with Robert. She has secretly always hoped for Robert, but Alcee is conveniently there. Sick of her old life, Edna simply takes up Alcee as a lover for the companionship. In a sense, she lives out her relationship-fantasy of Robert with Alcee. Why do you suppose critics were outraged at this novel in 1899, saying it committed â€Å"unutterable crimes against polite society† and should be labeled â€Å"poison† to protect â€Å"moral babes†? The story showed a women reaching the ultimate low because of rules society layed out. She killed herself because she felt that everything constricted her too much. I think that the reason they called it so horrible is because it showed the darker side to the norms of society. It also showed how oppressed women really were. What is your reaction to the end of the novel? Do you agree or disagree with the reasons for Edna's final action? I agree with her final action because I think too much damage had already been done. If she had gone back and told her husband she wanted a divorce, I think he would of brushed it away. She had a person who would of loved her and treated her like an equal. He saw that he had fallen in love with her and left to Mexico. The best oppertunity for her to get what she needed stepped out the door right then. The story also hints that she has always run away from her problems and not looked at them straight on. This means that all her problems have been building up over her life. I don't think that amount of damage is reversable.

Police Officer Essay

* Police officers work in partnership with the communities they serve to maintain law and order, protect members of the public and their property, prevent crime, reduce the fear of crime and improve the quality of life for all citizens. They use a wide range of technology to protect individuals, identify the perpetrators of crime and ensure successful prosecutions against those who break the law. Police officers work closely with members of the criminal justice system, social workers, schools, local businesses, health trusts, housing authorities, town planners and community groups to provide advice, education and assistance to those who wish to reduce crime or have been affected by crime. I chose to research this job because I like to help people and the best way I can imagine doing this is becoming a cop. * Many police departments require that applicants be high school graduates; an increasing number expect some college education. Applicants usually must be at least twenty-one years of age and U.S. citizens. In many communities, applicants must meet minimum requirements for height, weight, eyesight, and hearing. Because most police departments fall under civil service regulations, applicants must pass written tests that measure their analytical skills. Rigorous physical examinations and background checks are also required. New recruits often participate in formal classroom training in police academies. After graduating they continue to train on the job with experienced officers for three to twelve months. In small communities there may be no formal training program. Officers are usually encouraged to continue their education by taking college courses in criminal justice. Police Officers usually wear a uniform while on duty. Police work can be dangerous and stressful. Officers often deal with violent criminals and may be injured or killed. They must make quick decisions while on duty, yet be tactful and patient with people who are in trouble or have been victims of terrible crimes and abuse. Police protection is provided twenty-four hours a day, so officers may work outdoors in all kinds of weather. Work shifts are usually rotated; however, officers are on call at all times for emergencies. Overtime may be required. Earnings vary, depending on location. In 2004 the median salary for police officers was $45,210 per year. As officers advanced through the ranks, wages increased. The average minimum salary for police sergeants was $49,895 per year, while the average minimum for lieutenants was $56,115 per year. The following are some of the benefits provided to police officers: Family/Domestic partner health and dental plans for active employees and their eligible dependents. Sick leave disability benefits – Sworn employees receive twelve days of 100 percent paid sick leave, five days at 75 percent, and five days at 50 percent, upon hiring. Employees may accumulate up to 100 days at 100 percent, 75 percent, and 50 percent paid sick leave. Employees are eligible for a service-connected disability retirement from the date of graduation from basic training.

Treatment of Cbt Did - 7718 Words

Journal of Family Psychotherapy, 20:72–88, 2009 Copyright  © Taylor Francis Group, LLC ISSN: 0897-5353 print/1540-4080 online DOI: 10.1080/08975350802716566 Journal 1540-4080 0897-5353 WJFP of Family Psychotherapy, Vol. 20, No. 1, January 2009: pp. 1–25 Psychotherapy FAMILY THERAPY AND MENTAL HEALTH, Edited by Malcolm MacFarlane, M.A. A Systemic Approach to the Treatment of Dissociative Identity Disorder S. Pais Systemic Treatment of Dissociative Identity Disorder SHOBHA PAIS Department of Family Medicine, Indiana University, Indianapolis, Indiana, USA Although dissociative identity disorder (DID) continues to be questioned by some clinicians, those who work with this population understand the complexity of this†¦show more content†¦Essentially the self is believed to dissociate or split into separate and distinct personalities in an effort to repress the pain and suffering from some traumatic event. The diagnosis of DID is often associated with a history of significant traumatization, usually in childhood. DID clients have a higher rate of early childhood trauma than any other clinical group (Putnam et al., 1986). Severe, repetitive trauma can produce extreme states of experiences in children and can result in the development of discrete personified behavioral states (Putnam et al., 1986). Despite skepticism there has been considerable clinical recognition of dissociative conditions in the last several years resulting in significant progress in the diagnosis, assessment, and treatment of dissociative disorders and DID. DI D and dissociative disorders are not rare conditions. Clinical literature including case reports, treatment outcome studies, as well as studies of psychophysiology, neurobiology, and neuroimaging have been collected from numerous countries such as Australia, Canada, France, Germany, Great Britain, Italy, Israel, Japan, the Netherlands, New Zealand, Norway, Puerto Rico, Spain, Sweden, Switzerland, Spain, Turkey, and the United States (International Society for Study of Dissociation, 2005). The main difficulties in diagnosing DID 74 S. Pais result from lack of education among clinicians about dissociation, dissociative disorders, and the effects ofShow MoreRelatedCognitive Behavior Therapy And Other Treaments Essay970 Words   |  4 Pagestreated by Antidepressant Medication (ADM) or by non-drug treatment, such as Cognitive Behaviour Therapy (CBT). The aim of this review article is to explore what is the best treatment for depressed patient. 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